The blood vascular and lymphatic systems play important roles in tissue homeostasis and immune function. Growth of blood vessels, or angiogenesis, is required for tumor growth while lymphatic system is the primary route for carcinoma metastasis. Recently there is great interest in studying tumor lymphangiogenesis. Antibodies that can reliably distinguish lymphatic vessels from blood vessels at the histology level are valuable tools for such studies.

AngioBio now offers a complete series of antibodies against lymphatic markers Prox1, podoplanin, LYVE-1 and VEGFR3, most working well with formalin-fixed paraffin embedded (FFPE) sections. They have been tested and used with great success in histology and research labs.

Recent Publications citing AngioBio products:

1. Dontscho Kerjaschki, et.al., Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants. Nature Medicine, 2006, 12, 230 - 234
2. Ruediger Liersch, et.al., Induction of lymphatic endothelial cell differentiation in embryoid bodies. Blood. 2006, 107, 1214-1216.
3. Yasushi Nakamura, et.al Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer. Journal of Clinical Pathology 2006;59:77-82
4. Qu, Peng, Ji, Rui-Cheng, Kato, Seiji, Expression of CCL21 and 5'-Nase on Pancreatic Lymphatics in Nonobese Diabetic Mice. Pancreas. 2005, 31, 148-155
5. Kimura N, Kimura I. Podoplanin as a marker for mesothelioma. Pathol Int. 2005 Feb;55(2):83-6.
6. Yasuoka H, et.al. VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma. Modern Pathology. 2005 18(8):1127-33
7. Yasushi Nakamura, et.al. Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer. Breast Cancer Research and Treatment , 2005, 91(2), 125 - 132
8. Agarwal,B, et.al. Lymphangiogenesis Does Not Occur in Breast Cancer. American Journal of Surgical Pathology. 2005, 29(11):1449-1455
9. Nelson G. Ordóñez. Clear cell mesothelioma presenting as an incarcerated abdominal hernia. Virchows Archiv. 2005, 447, 823 - 827
10. Yasuhiko Kitadai, et.al. Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes. Int J Cancer. 2005 115: 388 - 392
11. Kaneko, M, et.al. Functional Sialylated O-Glycan to Platelet Aggregation on Aggrus (T1 /Podoplanin) Molecules Expressed in Chinese Hamster Ovary Cells. J. Biol. Chem., 2004. Vol. 279, 38838-38843
12. Schaerli P, et.al. A skin-selective homing mechanism for human immune surveillance T cells. J Exp Med. 2004;199(9):1265-75

Other products for lymphangiogenesis research include lymphatic endothelial growth factors VEGF-C(wild type), VEGF-C152S (binds Flt4 only), VEGF-E, soluble receptor sFlt4-Fc(which can be used as an inhibitor).

AngioBio has arrays of products for angiogenesis research. Most of our antibodies have been lab-tested to work for staining of FFPE sections, flow cytometry, Western blot or other application as specified. Antibodies against endothelial markers CD31, CD34, endoglin, VEGF isoforms, VEGFRs and much more are available. Please see Catalog for the complete list.