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anti-human LYVE-1
Overview
Description:
LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. LYVE-1 is the first lymph-specific HA receptor to be characterized. Later, LYVE-1 was reported to express in liver sinusoid blood vessels. However, in most tissues, LVYE-1 is a specific marker for lymph vessels.
Host Species: Rabbit Buffer: PBS Formulation: Rabbit IgG Stability: The antibody should be stored at –20°C. Cross-Reactivity: The antibody has not been showed to cross-react with LYVE-1 from mouse or other species. Specificity: The antibody will detect human LYVE-1 on the surface of lymphatic endothelial cells by immunohistochemistry. The antibody detects a 70 KD LYVE-1 band in Western blotting. Immunohistochemistry: Use at 1:100 dilution. A boiling step is recommended when staining paraffin embedded sections. Western blotting: Use at 1:200 dilution with the appropriate secondary reagents. Optimal dilutions should be determined by each laboratory for each application. Usage: This antibody is offered for research use only. Not for human use! Image
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